PARP INHIBITOR OLAPARIB OVERCOMES SORAFENIB RESISTANCE THROUGH RESHAPING THE PLURIPOTENT TRANSCRIPTOME IN HEPATOCELLULAR CARCINOMA

PARP inhibitor Olaparib overcomes Sorafenib resistance through reshaping the pluripotent transcriptome in hepatocellular carcinoma

Abstract Hepatocellular carcinoma (HCC) is one of the most common human malignancies worldwide with very poor prognosis.Resistance to targeted therapeutic drugs such as sorafenib remains one of the major challenges in clinical treatment.In the present study, PARP1 was found to be highly expressed in human embryonic Parts stem cells, but progressive

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Near-Infrared Spectroscopy and Chemometrics for Effective Online Quality Monitoring and Process Control during Pelagic Fishmeal and Oil Processing

Near-infrared spectroscopy has become a common quality assessment tool for fishmeal products during the last two decades.However, to date it has not been used for active online quality monitoring during fishmeal processing.Our aim was to investigate whether NIR spectroscopy, in combination with multivariate chemometrics, could actively predict the

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